Impact of Some Inflammatory Markers (crp & Il8) on Anemia in Negative Microalbuminuric Diabetics

Diabetes represent’s the most common cause of renal anemia. Among the reported risk factors for the increased prevalence of anemia in both types of diabetes is the inflammation. Creactive protein (CRP) was formerly regarded as solely a biomarker for inflammation, is currently regarded as a prominent partaker in endothelial dysfunction, as well as, in atherosclerosis. Besides the previously reported that, chronic elevation of glucose levels causes induction of interleukin -8 (IL-8). These observations were analyzed and possible existence of significant correlations between anemia modulator; serum hepcidin levels and inflammatory markers (high sensitive Creactive protein and Interleukin-8) in anemic type1and type 2 diabetics with negative microalbuminuria. Eighty-six subjects were included, 20 of them were of type1 diabetes mellitus, 34 of type2, in addition to 32 of apparently healthy subjects as the control group. All of the diabetics were selected to have anemia ( Hb<13g/dl) , without overt kidney disease ( -ve microalbuminuria test). The result showed that Serum hepcidin levels exhibited significant elevations in both types of diabetes (>43% in type1 and ~35% in type 2). Serum hs-CRP levels were significantly lowered in type 1, wheareas its level was highly elevated in type 2diabetics.In contrary to IL-8 values were significantly elevated in type 1 specifically. Pearson's correlations studies exhibited significant correlations between CRP and renal function indicators; creatinine clearance (CCL) and serum urea in type 2,while IL-8 seems to be more related to glycemic index :HbA1C and to CCL , in type1 diabetes.